Olhava, E. J.: search on Z-Library

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1

Targeting epigenetic enzymes for drug discovery

Robert A Copeland, Edward J Olhava, Margaret Porter Scott

Journal:

Current Opinion in Chemical Biology

Year:

2010

Language:

english

File:

PDF, 251 KB

english, 2010

2

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan, Matthew S. J., Olhava, Edward J., Roush, William R., Seidel, H. Martin, Glick, Gary D., Latz, Eicke

Journal:

Nature Reviews Drug Discovery

Year:

2018

Language:

english

File:

PDF, 1.45 MB

english, 2018

3

Total Synthesis of (+)-Azaspiracid-1. Part II: Synthesis of the EFGHI Sulfone and Completion of the Synthesis

David A. Evans, Travis B. Dunn, Lisbet Kværnø, André Beauchemin, Brian Raymer, Edward J. Olhava, Jason A. Mulder, Martin Juhl, Katsuji Kagechika, David A. Favor

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 339 KB

english, 2007

4

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, Christina R. Majer, Christopher J. Sneeringer, Jeffrey Song, L. Danielle Johnston, Margaret Porter Scott, Jesse J. Smith, Yonghong Xiao, Lei Jin

Journal:

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

5

Chirale C2-symmetrische CuII-Komplexe als Katalysatoren für enantioselektive Hetero-Diels-Alder-Reaktionen

David A. Evans, Edward J. Olhava, Jeffrey S. Johnson, Jacob M. Janey

Journal:

Angewandte Chemie

Year:

1998

Language:

german

File:

PDF, 255 KB

german, 1998

6

Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human

Waters, Nigel J., Smith, Sherri A., Olhava, Edward J., Duncan, Kenneth W., Burton, Richard D., O’Neill, James, Rodrigue, Marie-Eve, Pollock, Roy M., Moyer, Mikel P., Chesworth, Richard

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.78 MB

english, 2016

7

Mechanisms of Pinometostat (EPZ-5676) Treatment Emergent Resistance in MLL Rearranged Leukemia

Campbell, Carly T., Haladyna, Jessica N., Drubin, David A., Thomson, Ty M., Maria, Michael J., Yamauchi, Taylor, Waters, Nigel J., Olhava, Edward J., Pollock, Roy M., Smith, Jesse J., Copeland, Robert

Journal:

Molecular Cancer Therapeutics

Year:

2017

Language:

english

File:

PDF, 1001 KB

english, 2017

8

Total Synthesis of (+)-Azaspiracid-1. Part I: Synthesis of the Fully Elaborated ABCD Aldehyde

David A. Evans, Lisbet Kværnø, Jason A. Mulder, Brian Raymer, Travis B. Dunn, André Beauchemin, Edward J. Olhava, Martin Juhl, Katsuji Kagechika

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 278 KB

english, 2007

9

Total Synthesis of (+)-Azaspiracid-1. Part I: Synthesis of the Fully Elaborated ABCD Aldehyde

David A. Evans, Lisbet Kværnø, Jason A. Mulder, Brian Raymer, Travis B. Dunn, André Beauchemin, Edward J. Olhava, Martin Juhl, Katsuji Kagechika

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 277 KB

english, 2007

10

Total Synthesis of (+)-Azaspiracid-1. Part II: Synthesis of the EFGHI Sulfone and Completion of the Synthesis

David A. Evans, Travis B. Dunn, Lisbet Kværnø, André Beauchemin, Brian Raymer, Edward J. Olhava, Jason A. Mulder, Martin Juhl, Katsuji Kagechika, David A. Favor

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 341 KB

english, 2007

11

Synthesis of (+)-Azaspiracid-1

Evans, D., Dunn, T., Kværnø, L., Beauchemin, A., Raymer, B., Olhava, E., Mulder, J., Juhl, M., Kagechika, K., Favor, D.

Journal:

Year:

2007

Language:

english

File:

PDF, 64 KB

english, 2007

12

ChemInform Abstract: Enantioselective Synthesis of Dihydropyrans. Catalysis of Hetero Diels—Alder Reactions by Bis(oxazoline) Copper(II) Complexes.

David A. Evans, Jeffrey S. Johnson, Edward J. Olhava

Journal:

Year:

2000

Language:

english

File:

PDF, 40 KB

english, 2000

13

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

Blackburn, C., Gigstad, K. M., Hales, P., Garcia, K., Jones, M., Bruzzese, F. J., Barrett, C., Liu, J. X., Soucy, T. A., Sappal, D. S., Bump, N., Olhava, E. J., Fleming, P., Dick, L. R., Tsu, C., Sint

Journal:

Biochemical Journal

Year:

2010

Language:

english

File:

PDF, 27 KB

english, 2010

14

Enantioselective Synthesis of Dihydropyrans. Catalysis of Hetero Diels−Alder Reactions by Bis(oxazoline) Copper(II) Complexes

Evans, David A., Johnson, Jeffrey S., Olhava, Edward J.

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 356 KB

english, 2000

15

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Daigle, S. R., Olhava, E. J., Therkelsen, C. A., Basavapathruni, A., Jin, L., Boriack-Sjodin, P. A., Allain, C. J., Klaus, C. R., Raimondi, A., Scott, M. P., Waters, N. J., Chesworth, R., Moyer, M. P.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.43 MB

english, 2013

16

Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target

Waters, Nigel J., Daigle, Scott R., Rehlaender, Bruce N., Basavapathruni, Aravind, Campbell, Carly T., Jensen, Tyler B., Truitt, Brett F., Olhava, Edward J., Pollock, Roy M., Stickland, Kim A., Dovlet

Journal:

Journal of Controlled Release

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

17

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

Basavapathruni, Aravind, Olhava, Edward J., Daigle, Scott R., Therkelsen, Carly A., Jin, Lei, Boriack-Sjodin, P. Ann, Allain, Christina J., Klaus, Christine R., Raimondi, Alejandra, Scott, Margaret Po

Journal:

Biopharmaceutics & Drug Disposition

Year:

2014

Language:

english

File:

PDF, 770 KB

english, 2014

18

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

Kuhn, M. W. M., Hadler, M. J., Daigle, S. R., Koche, R. P., Krivtsov, A. V., Olhava, E. J., Caligiuri, M. A., Huang, G., Bradner, J. E., Pollock, R. M., Armstrong, S. A.

Journal:

Year:

2015

Language:

english

File:

PDF, 569 KB

english, 2015

19

ChemInform Abstract: Chiral C2-Symmetric CuII Complexes as Catalysts for Enantioselective Hetero-Diels—Alder Reactions.

David A. Evans, Edward J. Olhava, Jeffrey S. Johnson, Jacob M. Janey

Journal:

Year:

1999

File:

PDF, 39 KB

1999

20

DOT1L Inhibitor EPZ-5676 Displays Synergistic Antiproliferative Activity in Combination with Standard of Care Drugs and Hypomethylating Agents in MLL-Rearranged Leukemia Cells

Klaus, C. R., Iwanowicz, D., Johnston, D., Campbell, C. A., Smith, J. J., Moyer, M. P., Copeland, R. A., Olhava, E. J., Scott, M. P., Pollock, R. M., Daigle, S. R., Raimondi, A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

21

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan, Matthew S. J., Olhava, Edward J., Roush, William R., Seidel, H. Martin, Glick, Gary D., Latz, Eicke

Journal:

Nature Reviews Drug Discovery

Year:

2018

File:

PDF, 56 KB

2018

22

Total Synthesis of (+)-Azaspiracid-1. An Exhibition of the Intricacies of Complex Molecule Synthesis

Evans, David A., Kværnø, Lisbet, Dunn, Travis B., Beauchemin, André, Raymer, Brian, Mulder, Jason A., Olhava, Edward J., Juhl, Martin, Kagechika, Katsuji, Favor, David A.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 1.62 MB

english, 2008

23

Chiral C2-Symmetric CuII Complexes as Catalysts for Enantioselective Hetero-Diels–Alder Reactions

David A. Evans, Edward J. Olhava, Jeffrey S. Johnson, Jacob M. Janey

Journal:

Angewandte Chemie International Edition

Year:

1998

Language:

english

File:

PDF, 136 KB

english, 1998

24

Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l

Chen, L, Deshpande, A J, Banka, D, Bernt, K M, Dias, S, Buske, C, Olhava, E J, Daigle, S R, Richon, V M, Pollock, R M, Armstrong, S A

Journal:

Year:

2013

Language:

english

File:

PDF, 1.83 MB

english, 2013

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